Preparation and characterization of nanoporous sodium. Carboxy methyl starch cms carboxy methyl starch cms is a watersoluble polysaccharide which is widely employed as an additive. It used to be marketed under the name tylose, a registered. Viscoelastic and rheological properties of carboxymethyl. The cms is an important starch derivative with advantages of being renewable, biodegradable, and environmentally friendly. Carboxymethyl starchalginate microspheres containing diamine. Homogeneous structure of starch is obtained by starch pregelatinized with heat treatment before the copolymerization 8, 9. Preparation, optimization and swelling study of carboxymethyl sago starch cmssacid hydrogel article pdf available in chemistry central journal 121 december 2018 with 147 reads.
The products varied in their degree of substitution ds average number of carboxymethyl groups per monomer unit and crosslinker ratio fz number of crosslinker molecules offered per monomer. Synthesis of carboxymethylcellulosestarch superabsorbent hydrogels by gammairradiation. When compared to corresponding films from corn starch, mango kernel starch films exhibits improved tensile strength and elastic modulus, but higher opacity. Carboxymethyl starch is synthesized by fast reactive extrusion process in glycerol plasticized medium. One of the most common modification methods is carboxymethylation, from which carboxymethyl starch cms can be obtained by converting the hydroxyl group on natural starch into a carboxyl group. Radiation crosslinking of carboxymethyl starch request pdf. Polymers free fulltext fabrication and optimization. Carboxymethylcellulose cmc is a commercially available watersoluble cellulose derivative of major interest in the hydrogel synthesis. Superabsorbent hydrogels show a large potential in a wide array of applications due to their unique properties. The association of carboxymethyl starch cms and alginate is proposed as a novel matrix for the entrapment of bioactive agents in microspheres affording their protection against gastrointestinal degradation. Carboxymethylcellulose and potato starch powder were mixed with blend ratios from 100. Pdf preparation, optimization and swelling study of.
By the interaction of several favorable properties ultramyl ensures a rapid and complete disintegration of the tablet as soon as it comes into contact with water. Carboxymethyl starch cms was used as printing thickener, it was synthesized by carboxymethylation reaction with acidhydrolyzed maize starch and chloroacetic acidmca. Hydrogel dressing can protect injured skin and keep it appropriately moist to speed the healing process. Pdf abstract in this study, sago starch was modified in order to enhance its physicochemical properties. Preparation and characterization of nanoporous sodium carboxymethyl cellulose hydrogel beads. Its freeradical crosslinking can be initiated either by initiator system. The morphological observation of hydrogels reveals the porous structure for the. Besides, the natural polymers are cheap as compared to the synthetic polymers. The diffusion coefficient of gatifloxacin, a fourth generation fluoroquinolone, was determined through the prepared starch hydrogel membrane using a diaphragm cell technique. A new biodegradable starch derivative hydrogel, carboxymethyl starch cms hydrogel, was synthesized by irradiation in high concentrated solution in the socalled pastelike condition. The potential use of carboxymethyl sago pulp cmsp extracted from sago waste for producing hydrogel nanofibers was investigated as a methylene blue drug carrier.
The carboxymethyl sago starch cmss was used to prepare smart hydrogel by adding acetic acid into the cmss. Synthesis of carboxymethylcellulosestarch superabsorbent. Controlled release is a system that delivers desirable substances or agents in the controlled rate in term of time, ph or temperature. Water absorption capacity wac, ftir, sem, dsc, cho, flame photometer and ignition tests are carried out to determine the used cmc formula, investigate the crosslinking process, and suggest a crosslinking model. Synthesis and characterization superabsorbent hydrogels.
The structure and properties of starchepichlorohydrincarboxymethyl hydrogel were measured by sem, ftir, water and physiological solution absorption test and water retention test. Sodium carboxy methyl starch cms or scms is a starch ether derivative derived from starch. The reactor was immersed in a thermostated water bath. Pdf synthesis of carboxymethyl starchbiobased epoxy. High specific mechanical energy sme provides high reaction yields in a very short reaction time.
Researcharticle preparation and characterization of nanoporous sodium carboxymethyl cellulose hydrogel beads gulenoytunakalin 1 andmehlikapulat2 scientic. In literature were reported several preparation methods of bc based composites like. The structure and properties of starch epichlorohydrin carboxymethyl hydrogel were measured by sem, ftir, water and physiological solution absorption test and water retention test. The objective of the present study was to develop carboxymethyl starch cms and dextran sulfate ds hydrogels that are able to efficiently encapsulate 5,10,15,20tetrakismesohydroxyphenylporphyrin mthpp, a porphyrinbased ps agent. Their swelling improved with added carboxymethyl group on the starch epichlorohydrin structure. Sago pulp was chemically modified via carboxymethylation reaction to form carboxymethyl sago pulp cmsp and subsequently used to produce nanofibers using the electrospinning method. Biodegradability of blend hydrogels based on carboxymethyl. Crosslinked carboxymethyl starch cms was synthesized from potato starch in a single. At 30c, the measured value of the diffusion coefficient for gatifloxacin was approximately 3. Most commonly alkyl, hydroxyalkyl and carboxymethyl functional. In distilled water dwater, the water retention value wrv of the newly fabricated hydrogels reached 725 g dwaterg. Hydrogels were synthesized with carboxymethyl starch and. Cmcstarch hydrogels may offer a cheaper, superior alternative. International journal of chemical engineering hindawi.
Hydrogels based on cellulose comprising many organic biopolymers including cellulose, chitin, and chitosan are the hydrophilic material, which can absorb and retain a huge proportion of water in the interstitial sites of their structures. Chemically, it is a low substituted sodium carboxymethyl starch, also called sodium starch glycolate. Composite hydrogels of bacterial cellulose carboxymethyl. The ionic groups within the hydrogel structure respond towards external changes such as ph, ionic strength and temperature which consequently influence the uptake and.
Cmccs and aacs hydrogels were amorphous and porous threedimensional networks, with smaller pores at higher anionic. Highenergy irradiation allows the chemical crosslinking without the use of crosslinking agents, while the introduction of other natural or. Carboxymethyl cellulose cmc or cellulose gum is a cellulose derivative with carboxymethyl groups ch 2 cooh bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone. The hydrogels are physically characterized by the swelling ratio and gel fraction. It is soluble in water at room temperature and forms a transparent to light milky and viscous solution. The current work reports the synthesis of carboxymethyl cellulose cmc and xylanbased homopolymerized as well as copolymerized hydrogels using an ethylene glycol diglycidyl ether crosslinker in alkaline medium. Removal of dyes and heavy metal ions from water by.
Us20050092964a1 us10944,061 us94406104a us2005092964a1 us 20050092964 a1 us20050092964 a1 us 20050092964a1 us 94406104 a us94406104 a us 94406104a us 2005092964 a1 us2005092964 a1 us 2005092964a1 authority us united states prior art keywords cross starch ch linked linked carboxymethyl prior art date 20030919 legal status the legal status is an assumption. Mar 04, 2019 the current work reports the synthesis of carboxymethyl cellulose cmc and xylanbased homopolymerized as well as copolymerized hydrogels using an ethylene glycol diglycidyl ether crosslinker in alkaline medium. Crosslinking of hydrogels can be achieved by initiator system or by high energy irradiation which give free radical crosslinking and are having very high swelling capabilities. Carboxymethyl starchalginate microspheres containing. It is often used as its sodium salt, sodium carboxymethyl cellulose. Synthesis of sodium carboxymethyl starch from high amylose starch for the application of controlled release matrix for oral medications has been reported in. Superabsorbent polymer sap blend has been synthesized from carboxymethyl cellulose cmc, starch, and aluminum sulfate octadecahydrate crosslinker. Pdf preparation, optimization and swelling study of carboxymethyl. In situ hydrogel constructed by starch based nanoparticle and polyvinylamine via a schiff base reaction is used to test the controlled release of doxorubicin. The invention provides a kind of low concentration low degree of substitution carboxymethyl curdlan aqueous solution or hydrogel and its preparation method and application. Cms is an anionic starch modified by treatment with monochloroacetic acid in order to introduce carboxylic groups by etherification. Starchbased hydrogels combined with other renewable materials were not studied indepth. The carboxymethyl sago starch cmss was used to prepare smart hydrogel by adding acetic acid into the cmss powder as the crosslinking agent. Citric acid crosslinked carboxymethyl cellulosebased.
The study showed that the lifetime of the triplet state for porphyrin ps is significantly increase when encapsulate into hydrogel. In distilled water dwater, the water retention value wrv of the newly fabricated hydrogels reached 725. The optimum conditions of synthesized cms were as follows. Starch and starch nanocrystals snc are extracted from mango kernels and used for bionanocomposite films. Characterization of different substituted carboxymethyl. Hydrogel prepared from biomaterials specifically from. Improving uniformity, taste, fineness and crispness. The effect of starch content on the gel fraction a and on the degree of swelling b of cmc starch hydrogels 20 ww% solution, absorbed doses. Viscoelastic and rheological properties of these two hydrogels were studied and compared. The authors are not aware of any previous publication on hydrogels synthesized from carboxymethyl cassava starch. After complete dissolution of the starch, sodium hydroxide 10. Some of the wellknown natural polymers used for the preparation of hydrogels include cellulose10, starch 11, chitosan12, sodium alginate. Hydrogels based on carboxymethyl cassava starch cross.
Synthesis of carboxymethyl starch biobased epoxy resin and their impact on mechanical properties article pdf available in zeitschrift fur physikalische chemie august 2019 with 770 reads. Starch was first dissolved into water to form gellike solution and then added to pva solution, continuously stirred to form homogeneous mixture after heating at 90 o c for 30 mins. Carboxymethyl starch cms is a biodegradable polymer that has been proposed as an excipient for controlled release of small molecules and bioactive agents in oral solid monolithic tablets dosage forms 16. Modern dressings increase the woundhealing rate rather than just to cover it. The design and development of novel membrane of hydrogels prepared by crosslinking of polyvinyl alcohol with heattreated cornstarch suspension was attempted. Viscoelastic and rheological properties of carboxymethyl cellulose starchgraphite oxide as superabsorbent hydrogel nano composites shncs auda jabbar braihi 1, sihama issa salih 2, fadhel abbas hashem 2 1babylon university, college of materials engineering, polymer and petrochemical industries department, babylon, iraq. Some properties of chemical crosslinking biohydrogel from. The physicochemical properties of microgels in various degrees of substitution ds were determined by thermal gravimetric analysis tga, swelling degree, and rheological analysis. It was followed by the gel degradation and the decrease of the swelling ratio.
Carboxymethyl cellulose chitosan full text html polymers. Synthesis of carboxymethylcellulosestarch superabsorbent hydrogels by gammairradiation article pdf available in chemistry central journal 111 may 2017 with 263 reads how we measure reads. Preparation and characterization of superabsorbent polymers. The degree of substitution of the cmss obtained was 0. Carboxymethyl starchalginate microspheres containing diamine oxidase for intestinal targeting lindsay blemur1 tien canh le1 lucia marcocci2 paola pietrangeli2 mircea alexandru mateescu1. Pdf preparation of transparent starch based hydrogel. Application carboxymethyl starch high degree of substitution synthesis 1 introduction products based on starch are potentially renewable, biodegradable and environmentally friendly 1. Uncrosslinked carboxymethyl cellulose cmc starch blend used to prepare two hydrogels. Hydrogels were synthesized with carboxymethyl starch and carboxymethylcellulose in the presence of mba crosslinker 15.
Differences in morphology, ph, and electric charge of chitosan cs based hydrogels prepared by complexation with carboxymethylcellulose cmc, carboxymethylated starch cms, and alginic acid aa at different polymers ratios and changing the order of addition were studied. Cms is an important modified starch with unique properties due to the presence of negatively charged functional group ch2coo. The free swelling capacities fsc vary between 77 gg for the 12. Viscoelastic and rheological properties of carboxymethyl cellulose starch graphite oxide as superabsorbent hydrogel nano composites shncs auda jabbar braihi 1, sihama issa salih 2, fadhel abbas hashem 2 1babylon university, college of materials engineering, polymer and petrochemical industries department, babylon, iraq. Hydrogel is often produced using chemical or physical crosslinking methods to form a threedimensional polymeric structure capable of retaining water or biological fluid beyond its dry weight without dissolution in water 6,7,8. A crosslinked carboxymethyl starch is described for use as an absorbent for water, whereby the crosslinking in part or in full takes place via diether bridges, which are formed between neighbouring polymer chains. The degree of substitution ds of cms samples was determined via determination of the carboxyl content according to liu et. Present status and applications article pdf available in international journal of polymeric materials 627. Sodium carboxy methyl starch cms sunray international. Similarly, carboxymethylcellulose is mostly applied in copolymers with other cellulose derivatives , 31.
In this study, the enzyme diamine oxidase dao from white pea lathyrus sativuswas immobilized by inclusion in microspheres formed by. These polymers feature many amazing properties such as responsiveness to ph, time, temperature, chemical species and biological conditions besides a very. Sago starch based hydrogel prepared using electron beam irradiation technique for controlled release application 504 controlled release for drug delivery. A significant decrease in the disintegration time of almost all formulations can be. Preparation and application of carboxymethyl starch. In this work, the thermosensitive materials nisopropylacrylamide nipam and acrylic acid aa were crosslinked with carboxymethyl cellulose cmc cmcp nipamcoaa via a free radical polymerization method for the removal of uvi from aqueous solution. Characterization of superabsorbent hydrogel based on.
Proposed crosslinking model for carboxymethyl cellulose. However, the shortcomings of native potato starch, such as the lack of free. Starch based hydrogels combined with other renewable materials were not studied indepth. Their swelling improved with added carboxymethyl group on the starchepichlorohydrin structure. Hydrogel nanofibers from carboxymethyl sago pulp and its. Jul 10, 2017 superabsorbent hydrogel was prepared by epichlorohydrin crosslink of cassava starch. A carboxymethyl starch cms microgel system was prepared for the control of uptaking and releasing proteins lysozyme. Hydrogels based on carboxymethyl cassava starch crosslinked. Mali et al carboxymethyl cellulosebased hydrogel films for drug delivery the objective of this study was to synthesize and characterize citric acid crosslinked hydrogel films of carboxymethyl cellulosetamarind gum for topical drug delivery. Carboxymethyl starch cms was prepared using waxy corn starch according to the reported method in our laboratory.
Pdf synthesis of carboxymethylcellulosestarch superabsorbent. Cmcstarch hydrogels may offer a cheaper, superior alternative compared to pure cellulose. The l16 45 orthogonal experiments were designed for the optimization of the synthesis condition. Biodegradable blend hydrogels based on carboxymethyl cellulose cmc and carboxymethyl starch cms were prepared by the radiationinduced crosslinking. Researcharticle effect of experimental parameters on the formation of hydrogels by polyelectrolyte complexation of carboxymethylcellulose, carboxymethyl starch, and alginic. In situ hydrogel constructed by starchbased nanoparticle and polyvinylamine via a schiff base reaction is used to test the controlled release of doxorubicin. Cmccs and aacs hydrogels were amorphous and porous threedimensional networks, with smaller pores at higher. The main aim of current research was to develop a novel magnetically responsive hydrogel by radical polymerization of carboxymethyl cellulose cmc on acryl amide am using n,nmethylene bis acrylamide mba as a crosslinking agent, potassium persulfate kps as a free radical initiator, and magnetic montmorillonite mmt nanoclay as nanofiller. The effect of the solution concentration on the crosslinking of cms, the properties of formed hydrogel and the biodegradability were investigated. Properties of the crosslinked cmccms blend hydrogels such as gel fraction, degree of swelling sw, gel. Sugar dextrins can also plasticize the reaction medium. Preparation and characterization of superabsorbent. Sodium carboxy methyl starch referred to as cms is a starch ether derivative derived from starch.
There have been many studies using starch 4, carboxymethyl. Removal of dyes and heavy metal ions from water by magnetic. Effect of experimental parameters on the formation of. Sustainable production of cellulosebased hydrogels with. Carboxymethyl cellulose chitosan full text html polymers posted on. Properties of the crosslinked cmccms blend hydrogels such as gel fraction, degree of swelling sw, gel strength, and biodegradability were investigated. The preparation method of the present invention is simple, can form fullbodied aqueous solution or hydrogel, and the preparation of hydrogel is without adding other organic solvent any or chemical crosslinking agent under. Therefore, this work concerns functional and rheological properties of hydrogels made from crosslinked carboxymethyl cassava starch, which has the potentials of being used as biodegradable absorbent based on renewable resources. Superabsorbent hydrogel was prepared by epichlorohydrin crosslink of cassava starch. The morphological observation of hydrogels reveals the porous structure for the copolymerized gels. Carboxymethyl cellulosebased hydrogel films for drug delivery.
1268 1556 1201 534 997 39 265 1343 220 1609 805 1140 1182 873 588 309 1370 1297 1539 1437 404 1271 766 162 290 541 868 628 1032 1305 463 199 150 620 672 827 1427 693 1467 503 839 742 62 1319